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Progressive Vison Loss, A Rare Manifestation of Familial Cavernous Angiomas Arch Neurol 49:170-173, Malik,S.,et al, 1992 See this aricle in Pubmed Article Abstract We studied four generations of a family in which the index case had progressive loss of vision secondary to a cavernous angioma of the optic nerve and chiasm.Magnetic resonance imaging of the brain revealed multiple,asymptomatic intracerebral cavernous angiomas.Brain magnetic resonance imaging scans of the family members revealed multiple cavernous angiomas in the brother and paternal grandfather,but none in the father or his siblings.Autopsy reports of the paternal great grandfather noted multiple cavernous angiomas in the brain and abdominal viscera.We believe our patient to be the sixth reported case in which a cavernous angioma involved the optic chiasm and optic nerve.Magnetic resonance imaging is a sensitive and specific method of detecting cavernous angiomas.Cavernous angiomas have an autosomal dominant pattern of inheritance with variable penetrance.Surgical intervention in patients with symptomatic cavernous angiomas depends on the location and size of the lesion and associated surgical risks.

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(click to filter results - removes previous filter) cavernous hemangioma chiasmal syndromes familial genetic neurologic disorders malformation,vascular malformation,vascular,cerebral malformation,vascular,familial MRI MRI,abnormal optic chiasm optic nerve optic nerve,lesion of visual loss

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